Squamous cell carcinoma of the lip after allogeneic hemopoietic stem cell transplantation
Dermatology Unit and Department of Oncology, King Faisal Specialist Hospital and Research Centre.,Riyadh, Saudi Arabia
Hamadah I, Binamer Y, Alajlan S, Nassar A, Saleh AJM. Squamous cell carcinoma of the lip after allogeneic hemopoietic stem cell transplantation. Hematol Oncol Stem Cell Ther 2010; 3(2): 84-88.
DOI: 10.5144/1658-3876.2010.84 PMID: 20543542
Abstract
Allogeneic hemopoietic stem cell transplantation (HSCT) has been considered a curative treatment option for many hematological and non-hematological disorders. Despite the use of advanced methods of tissue typing and new therapies, graft versus host disease (GVHD) remains a major obstacle. Secondary malignancies are also among the most serious long-term complications after HSCT including leukemia, lymphomas, and to a lesser extent, solid tumors. The most commonly observed solid tumor is squamous cell carcinoma (SCC). We report two cases of SCC of the lower lip diagnosed several years after HSCT. Both cases were complicated with GVHD prior to the development of SCC and had a successful outcome with minimal surgical intervention.
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